Conor Finlay Lab Website Trinity Kidney Centre, Trinity Translational Medicine Insitute, Trinity College Dublin

Research

Cellular immunology, autoimmunity, type 2 immune responses, single cell omics, kidney disease, pleural disease.

Highlighted

T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H.K. Chan, Jesuthas Ajendra, …, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Rückerl, Judith E. Allen
Immunity  ·  01 May 2023  ·  doi:10.1016/j.immuni.2023.02.016

All

2024

Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
Amrita Dwivedi, Aisling Ui Mhaonaigh, Makala Carroll, Bahareh Khosravi, Isabella Batten, …, Sabina Mason, Niall Conlon, Clíona Ni Cheallaigh, Conor M. Finlay, Mark A. Little
JCI Insight  ·  10 Sep 2024  ·  doi:10.1172/jci.insight.171659
Lin-CD117 CD34 FceRI progenitor cells are elevated in atopic dermatitis
Lin-CD117+CD34+FceRI+ progenitor cells are elevated in atopic dermatitis
Katie Ridge, Barry Moran, Mark Little, Cliona O’Farrelly, Jean Dunne, Julianne Clowry, Clodagh Loftus, Conor M. Finlay, Alan Irvine, Niall Conlon
Authorea, Inc.  ·  28 Aug 2024  ·  doi:10.22541/au.172487286.61322662/v1
Lin sup sup CD117 sup sup CD34 sup sup FcεRI sup sup progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti scp IgE scp therapy
Lin−CD117+CD34+FcεRI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti‐IgE therapy
Katie Ridge, Barry Moran, P. Abigail Alvarado‐Vazquez, Jenny Hallgren, Mark A. Little, Alan D. Irvine, Cliona O’Farrelly, Jean Dunne, Conor M. Finlay, Niall Conlon
Allergy  ·  17 Apr 2024  ·  doi:10.1111/all.16127
IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging
IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging
Conor M. Finlay, Judith E. Allen
Immunity  ·  01 Mar 2024  ·  doi:10.1016/j.immuni.2024.02.013

2023

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species
Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species
Jichang Han, Alexandre Gallerand, Emma C. Erlich, Beth A. Helmink, Iris Mair, …, Claudia V. Jakubzick, Kathryn J. Else, Emily J. Onufer, Nan Zhang, Gwendalyn J. Randolph
Nature Immunology  ·  15 Dec 2023  ·  doi:10.1038/s41590-023-01688-7
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H.K. Chan, Jesuthas Ajendra, …, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Rückerl, Judith E. Allen
Immunity  ·  01 May 2023  ·  doi:10.1016/j.immuni.2023.02.016
In-depth comparison of human serous cavity resident macrophages and dendritic cells to their murine counterparts
In-depth comparison of human serous cavity resident macrophages and dendritic cells to their murine counterparts
Gwendalyn Randolph, Jichang Han, Alexandre Gallerand, Emma Erlich, Beth Helmink, …, Judith Allen, Claudia Jakubzick, Kathryn Else, Emily Onufer, Nan Zhang
Research Square Platform LLC  ·  22 Mar 2023  ·  doi:10.21203/rs.3.rs-2689141/v1
A subset of CD4 effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ
A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ
CP McEntee, S Houston, CM Finlay, S Rossi, G Liu, …, T Hussell, PM Hansbro, J-M Schwartz, H Paidassi, MA Travis
Cold Spring Harbor Laboratory  ·  02 Mar 2023  ·  doi:10.1101/2023.03.02.527395

2022

Hydra 2022: return of the interactive conference on helminth parasitology after the pandemic
Hydra 2022: return of the interactive conference on helminth parasitology after the pandemic
Caitlin M. McManus, Tiffany Bouchery, Mona Suleiman, Anna O. Kildemoes, Annabel Ferguson, …, Ryan Chan, Tess Renahan, Ananya Mukundan, Gyaviira Nkurunungi, Sarah D. Bobardt
Trends in Parasitology  ·  01 Dec 2022  ·  doi:10.1016/j.pt.2022.09.013

2021

Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity
Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity
Conor M Finlay, James E Parkinson, Brian HK Chan, Jesuthas Ajendra, Alistair Chenery, …, Louis Boon, Andrew S MacDonald, Joanne E Konkel, Dominik Rückerl, Judith E Allen
Cold Spring Harbor Laboratory  ·  19 Dec 2021  ·  doi:10.1101/2021.12.17.472661
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.
Rémi Fiancette, Conor M Finlay, Claire Willis, Sarah L Bevington, Jake Soley, Sky T H Ng, Syed Murtuza Baker, Simon Andrews, Matthew R Hepworth, David R Withers
Nature immunology  ·  23 Sep 2021  ·  pmid:34556884
Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease
Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease
Kyle T. Cunningham, Conor M. Finlay, Kingston H. G. Mills
The Journal of Immunology  ·  01 Apr 2021  ·  doi:10.4049/jimmunol.2001225

2020

IL-33 Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis
IL-33–Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis
Conor M. Finlay, Kyle T. Cunningham, Benjamin Doyle, Kingston H. G. Mills
The Journal of Immunology  ·  01 Oct 2020  ·  doi:10.4049/jimmunol.1901321
The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology.
The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology.
Conor M Finlay, Judith E Allen
Parasite immunology  ·  21 Mar 2020  ·  pmid:32145033

2019

Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley
Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley
Beata I. Czajkowska, Conor M. Finlay, Glynis Jones, Terence A. Brown
PLOS ONE  ·  05 Dec 2019  ·  doi:10.1371/journal.pone.0225899
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation
Craig P. McEntee, Conor M. Finlay, Ed C. Lavelle
Frontiers in Immunology  ·  07 Jun 2019  ·  doi:10.3389/fimmu.2019.01266

2018

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection
Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection
Sharon M Campbell, Johanna A Knipper, Dominik Ruckerl, Conor M Finlay, Nicola Logan, Carlos M Minutti, Matthias Mack, Stephen J Jenkins, Matthew D Taylor, Judith E Allen
eLife  ·  04 Jan 2018  ·  doi:10.7554/eLife.30947

2017

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
Caroline E Sutton, Conor M Finlay, Mathilde Raverdeau, James O Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A J O’Neill, Kingston H G Mills, Annie M Curtis
Nature communications  ·  12 Dec 2017  ·  pmid:29234010
Secreted products of i Fasciola hepatica i inhibit the induction of T cell responses that mediate allergy
Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy
C. M. Finlay, A. M. Stefanska, M. M. Coleman, H. Jahns, J. P. Cassidy, R. M. McLoughlin, K. H. G. Mills
Parasite Immunology  ·  06 Sep 2017  ·  doi:10.1111/pim.12460

2015

Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia.
Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia.
Conor M Finlay, Anna M Stefanska, Kevin P Walsh, Patrick J Kelly, Louis Boon, Ed C Lavelle, Patrick T Walsh, Kingston H G Mills
Journal of immunology (Baltimore, Md. : 1950)  ·  16 Dec 2015  ·  pmid:26673140
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis
N J Bernard, C M Finlay, G M Tannahill, J P Cassidy, L A O’Neill, K HG Mills
Mucosal Immunology  ·  01 Sep 2015  ·  doi:10.1038/mi.2014.125

2014

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
N J Bernard, C M Finlay, G M Tannahill, J P Cassidy, L A O’Neill, K H G Mills
Mucosal immunology  ·  17 Dec 2014  ·  pmid:25515629
Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases.
Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases.
Conor M Finlay, Kevin P Walsh, Kingston H G Mills
Immunological reviews  ·  01 May 2014  ·  pmid:24712468

2012

The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella pertussis.
The immunoregulatory role of CD4⁺ FoxP3⁺ CD25⁻ regulatory T cells in lungs of mice infected with Bordetella pertussis.
Michelle M Coleman, Conor M Finlay, Barry Moran, Joseph Keane, Pádraic J Dunne, Kingston H G Mills
FEMS immunology and medical microbiology  ·  18 Jan 2012  ·  pmid:22211712

2009

Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Kevin P Walsh, Miriam T Brady, Conor M Finlay, Louis Boon, Kingston H G Mills
Journal of immunology (Baltimore, Md. : 1950)  ·  08 Jul 2009  ·  pmid:19587018

1970

Open collaborative writing with Manubot
Open collaborative writing with Manubot
Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter
PLOS Computational Biology  ·  01 Jan 1970  ·  doi:10.1371/journal.pcbi.1007128
How type 2 cytokine signalling accelerates aquisition of macrophage tissue residency phenotypes.